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Understanding Ketamine Infusion Therapy: How It Works and What to Expect

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Ketamine, originally known as an anesthetic and a party drug, has emerged as a revolutionary treatment for various mental health conditions. Ketamine infusion therapy has been gaining traction for its rapid and often dramatic effects on depression, anxiety, PTSD, and chronic pain. This blog post delves into the science behind ketamine infusion therapy, its benefits, and a detailed guide on what patients can expect during their treatment sessions.

The Science Behind Ketamine Infusion Therapy

Mechanism of Action

Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist. Unlike traditional antidepressants that typically target serotonin or norepinephrine pathways, ketamine acts on the glutamate system, the most abundant neurotransmitter in the brain. By blocking NMDA receptors, ketamine enhances synaptic plasticity and connectivity in the brain, promoting the formation of new neural pathways. This process can lead to rapid mood improvement and relief from depressive symptoms.

Neuroplasticity and Synaptogenesis

One of the most fascinating aspects of ketamine is its ability to induce synaptogenesis, the formation of new synaptic connections between neurons. This effect is believed to play a crucial role in ketamine’s antidepressant properties. Studies have shown that ketamine can increase the density of dendritic spines, which are small protrusions on neurons that facilitate synaptic transmission.

Anti-Inflammatory Effects

Emerging research suggests that ketamine also has anti-inflammatory properties. Chronic inflammation is often linked to depression and other mental health disorders. By reducing inflammation, ketamine may further contribute to its therapeutic effects.

Rapid Onset of Action

Traditional antidepressants often take weeks to show noticeable effects. In contrast, ketamine can produce significant improvements in mood within hours or days. This rapid onset is particularly beneficial for patients with treatment-resistant depression or those experiencing suicidal ideation.

Conditions Treated with Ketamine Infusion Therapy


Ketamine infusion therapy has shown remarkable efficacy in treating major depressive disorder (MDD), especially in cases where patients have not responded to conventional treatments. Clinical trials have demonstrated that a single infusion of ketamine can produce rapid and sustained antidepressant effects.

Anxiety Disorders

Patients with generalized anxiety disorder (GAD) and social anxiety disorder (SAD) have also benefited from ketamine therapy. The anxiolytic effects of ketamine help in reducing the symptoms of anxiety, providing a new avenue for those who have not found relief with traditional medications.

Post-Traumatic Stress Disorder (PTSD)

PTSD is another condition where ketamine has shown promise. By modulating glutamate transmission and enhancing neuroplasticity, ketamine can help reduce the intrusive thoughts, hyperarousal, and emotional numbness associated with PTSD.

Chronic Pain

Ketamine’s analgesic properties make it a valuable option for managing chronic pain conditions such as fibromyalgia and complex regional pain syndrome (CRPS). It is thought to reduce central sensitization, a process where the nervous system becomes overly responsive to pain stimuli.

What to Expect During Ketamine Infusion Therapy

Pre-Treatment Consultation

Before starting ketamine infusion therapy, patients typically undergo a thorough medical evaluation. This includes a review of their medical history, current medications, and any previous treatments for their condition. The healthcare provider will also discuss the potential benefits and risks of ketamine therapy to ensure the patient is well-informed.

The Infusion Process

A Nura Therapy treatment room
Nura Therapy Treatment Rooms

Setting: Ketamine infusions are usually administered in a clinical setting, such as a hospital or specialized clinic. A key component to successful treatment is a calm and comfortable environment in which you undergo treatment. At Nura Therapy, we specifically designed each room to ensure a calm, relaxing and safe expereince so you feel at ease during your treatment. We have specifically chosen to use Perfect Chair Zero Gravity Classic Recliners and ultra-minimally intrusive monitors in order to not detract from your journey.

Administration: Ketamine is administered intravenously (IV) at a dose determined by the healthcare provider. The infusion typically lasts about 40 minutes to an hour. During this time, patients are monitored closely for any adverse reactions. Some clinics may offer additional support, such as a nurse or therapist, to stay with the patient throughout the session.

Sensations During Infusion: Patients may experience a variety of sensations during the infusion, including dissociation, where they feel detached from their body or surroundings. This is a common and expected effect of ketamine. Other sensations may include mild hallucinations, dizziness, or a sense of floating. These effects are generally temporary and subside shortly after the infusion ends.

Post-Infusion Monitoring

After the infusion, patients are typically monitored for about 30 minutes to an hour to ensure they have recovered from the acute effects of ketamine. It is recommended that patients have someone to drive them home, as they may feel drowsy or disoriented immediately following the treatment.

Frequency and Duration of Treatment

The initial treatment course usually consists of a series of six infusions over two to three weeks. After the initial series, maintenance infusions may be scheduled based on the patient’s response and ongoing needs. Some patients may require maintenance infusions every few weeks to months.

Potential Side Effects and Risks

Common Side Effects

Most side effects of ketamine infusion therapy are mild and transient. These can include:

• Nausea and vomiting

• Increased heart rate and blood pressure

• Drowsiness or dizziness


Ketamine infusion therapy represents a significant advancement in the treatment of various mental health and chronic pain conditions. Its unique mechanism of action, rapid onset of effects, and potential to help patients who have not responded to traditional treatments make it a valuable option in the field of psychiatry and pain management.

Patients considering ketamine infusion therapy should undergo a thorough evaluation and discuss the potential benefits and risks with their healthcare provider. Understanding what to expect during and after the treatment can help alleviate any concerns and ensure a smoother experience.

For those struggling with depression, anxiety, PTSD, or chronic pain, ketamine infusion therapy offers hope and a new path towards relief and recovery.


1. Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science. 2012 Oct 5;338(6103):68-72. doi: 10.1126/science.1222939. PMID: 23042884; PMCID: PMC4424898. Link

2. Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010 Aug 20;329(5994):959-64. doi: 10.1126/science.1190287. PMID: 20724638; PMCID: PMC3116441. Link

3. Machado-Vieira R, Salvadore G, Luckenbaugh DA, Manji HK, Zarate CA Jr. Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder. J Clin Psychiatry. 2008 Jun;69(6):946-58. doi: 10.4088/jcp.v69n0610. PMID: 18435563; PMCID: PMC2699451. Link

4. Zarate CA, Singh JB, Carlson PJ, et al. A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression. Arch Gen Psychiatry. 2006;63(8):856–864. doi:10.1001/archpsyc.63.8.856 Link

5. Murrough, J. W., Iosifescu, D. V., Chang, L. C., Al Jurdi, R. K., Green, C. E., Perez, A. M., … & Mathew, S. J. (2013). Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. American Journal of Psychiatry, 170(10), 1134-1142. Link

6. Feder, A., Parides, M. K., Murrough, J. W., Perez, A. M., Morgan, J. E., Saxena, S., … & Charney, D. S. (2014). Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry, 71(6), 681-688. Link

7. McGirr, A., Berlim, M. T., Bond, D. J., Fleck, M. P., Yatham, L. N., & Lam, R. W. (2015). A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the treatment of major depressive episodes. Psychological Medicine, 45(4), 693-704. Link

8. Schwartzman, R. J., & Patel, M. (2011). Chronic pain management: guidelines for multidisciplinary program development. CRC Press.

9. Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000). Antidepressant effects of ketamine in depressed patients. Biological Psychiatry, 47(4), 351-354. Link

10. Krystal, J. H., Karper, L. P., Seibyl, J. P., Freeman, G. K., Delaney, R., Bremner, J. D., … & Charney, D. S. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Archives of General Psychiatry, 51(3), 199-214.

11. Aan Het Rot, M., Zarate, C. A., Charney, D. S., & Mathew, S. J. (2012). Ketamine for depression: where do we go from here?. Biological Psychiatry, 72(7), 537-547.

12. Morgan, C. J., & Curran, H. V. (2012). Ketamine use: a review. Addiction, 107(1), 27-38.


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